The story revolves around the plight of Aaron Boone, a young man tormented by visions of monstrous, graveyard-dwelling creatures. Boone is led to believe by his doctor that he is a serial killer. Tracked down by the police, his doctor, and his girlfriend Lori, Boone eventually finds refuge in an abandoned cemetery called Midian among a "tribe" of mutant outcasts of varying types and abilities known as the "Nightbreed" that hide from humanity.